High tacrolimus trough level variability is associated with rejections after heart transplant
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منابع مشابه
Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant
Several neurological side effects induced by tacrolimus are described in the scientific literature, ranging from mild neurological symptoms to delirium and psychosis. We report the case of a 46-year-old man with no prior psychiatric history who suddenly manifested manic-like psychosis associated with elevated trough tacrolimus blood concentrations 17 years after kidney transplant. The use of an...
متن کاملNovel polymorphisms associated with tacrolimus trough concentrations: results from a multicenter kidney transplant consortium.
BACKGROUND The CYP4503A5*1 genotype is associated with lower tacrolimus concentrations. Although its effect is important, it incompletely explains the variability in tacrolimus concentrations and has a relatively low minor allele frequency in whites relative to African Americans (AA). METHODS We studied clinical and recipient genetic correlates of dose-normalized tacrolimus troughs (n=12,277)...
متن کاملGlucose metabolism in renal transplant recipients on tacrolimus: the effect of steroid withdrawal and tacrolimus trough level reduction.
The relative role of steroids and tacrolimus in the development of glucose metabolic disorders and hyperlipidemia after renal transplantation has not yet been clearly established. Therefore, glucose metabolism was prospectively evaluated by intravenous glucose tolerance test, as was lipid profile, in fifteen white nondiabetic renal transplant recipients three times: before and after steroid wit...
متن کاملHigh Blood Tacrolimus and Hyperkalemia in a Heart Transplant Patient
© 2017 Annals of Cardiac Anaesthesia | Published by Wolters Kluwer Medknow The Editor, A 43‐year‐old female patient (weight 54 kg) underwent orthotopic heart transplantation (OHT) for dilated cardiomyopathy. Postoperative recovery was uneventful and her left ventricle (LV) function was 60% on two‐dimensional echocardiography at the time of discharge. She was on immune suppressive therapy with t...
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Introduction: Previous cohort studies reported contradictory data on the association between subclinical thyroid dysfunction and coronary heart disease (CHD). Regarding this, the present study was conducted to illuminate this relationship. Materials and Methods: For the purpose of the study, 3,066 participants employed in a study conducted by Azizi et al. aged ≥ 20 years were subjected to thyro...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2018
ISSN: 1600-6135
DOI: 10.1111/ajt.15016